Staff of Domination + Cryptic Trilobite + Archangel of Thune + Cleric Class

Staff of Domination

Cryptic Trilobite

Archangel of Thune

Cleric Class

How it works

1. Activate Staff of Domination's second ability by paying 2 and tapping it, causing you to gain 2 life.
2. Archangel of Thune and Cleric Class trigger, putting two +1/+1 counters on Cryptic Trilobite and one +1/+1 counter on each other creature you control.
3. Activate Cryptic Trilobite by removing two +1/+1 counters from it, adding CCCC that can only be spent to activate abilities.
4. Activate Staff of Domination's first ability by paying 1, untapping it.
5. Repeat.

This loop turns a modest life-gain activation into an infinite engine by feeding its own growth. By paying two mana to gain life through Staff of Domination, you trigger both Archangel of Thune and Cleric Class to boost your creatures, which in turn amplifies Cryptic Trilobite so you can peel off +1/+1 counters for restricted ability-only mana. That generated mana readily untaps the Staff of Domination to start the whole cycle anew, leaving you with surplus counters, infinite life, and access to the rest of the Staff's powerful abilities.