The Golden Throne + Final Fortune + Isochron Scepter + Prototype Portal

The Golden Throne

Final Fortune

Isochron Scepter

Prototype Portal

How it works

1. Activate Isochron Scepter by paying 2 and tapping it, casting a copy of Final Fortune, causing you to take an extra turn after this one and to lose the game at the end of that turn.
2. Activate Prototype Portal by paying 4 and tapping it, creating a token copy of The Golden Throne.
3. Move to your next turn.
4. Activate Isochron Scepter by paying 2 and tapping it, casting a copy of Final Fortune, causing you to take an extra turn after this one and to lose the game at the end of that turn.
5. At the beginning of your end step, the delayed ability of one of the Final Fortune copies triggers, exiling the token The Golden Throne and setting your life total to 1.
6. Repeat from step 2.