Anhelo, the Painter + Twinning Staff + Repeated Reverberation + Vraska's Fall

Anhelo, the Painter

Twinning Staff

Repeated Reverberation

Vraska's Fall

How it works

1. Cast Repeated Reverberation by paying 2 and sacrificing a creature with power two or greater.
2. Repeated Reverberation's casualty ability triggers, creating two copies of it due to Twinning Staff.
3. Resolve each Repeated Reverberation, causing you to copy the next instant or sorcery spell you cast six times.
4. Cast Vraska's Fall by paying 2.
5. Each Repeated Reverberation triggers, copying Vraska's Fall a total of nine times due to Twinning Staff.
6. Resolve each Vraska's Fall, causing each opponent to get ten poison counters and sacrifice ten creatures and/or planeswalkers.
7. Each opponent loses the game due to having ten or more poison counters.