Vraska, Betrayal's Sting + Vorinclex, Monstrous Raider

Vraska, Betrayal's Sting

Vorinclex, Monstrous Raider

How it works

1. Cast Vraska by paying 4, causing it to enter with at least ten loyalty counters due to Vorinclex.
2. Activate Vraska's third loyalty ability by removing nine loyalty counters from it, causing target opponent to get enough poison counters such that they will have at least ten poison counters.
3. The opponent loses the game due to having ten or more poison counters.