Sire of Insanity + Necropotence + Harmless Offering + Teferi, Mage of Zhalfir

Sire of Insanity

Necropotence

Harmless Offering

Teferi, Mage of Zhalfir

How it works

1. Cast Harmless Offering by paying 2, giving Necropotence to an opponent.
2. The opponent skips their draw step due to Necropotence.
3. The opponent is unable to cast any cards put into their hand from Necropotence due to Teferi only allowing them to cast spells at any time they cast a sorcery.
4. At the beginning of each end step, Sire of Insanity triggers, causing all players to discard their hands.