Agatha's Soul Cauldron + Myojin of Blooming Dawn + Zopandrel, Hunger Dominus + Ajani's Welcome

Agatha's Soul Cauldron

Myojin of Blooming Dawn

Zopandrel, Hunger Dominus

Ajani's Welcome

How it works

1. Activate Zopandrel using Myojin of Blooming Dawn's ability by removing an indestructible counter from it, creating a 1/1 Spirit creature token for each permanent you control.
2. When the Spirits enter the battlefield, Ajani's Welcome triggers that many times, causing you to gain that much life.
3. Activate Zopandrel by paying 4 life and sacrificing two Spirits, putting an indestructible counter on it.
4. Repeat.
5. If you control at least two additional permanents as the combo starts, this combo nets infinite lifegain and creature tokens.

This loop relies on Agatha's Soul Cauldron to grant Myojin of Blooming Dawn's activated ability to Zopandrel, Hunger Dominus, turning the Dominus into a massive token generator by stripping away its indestructible counters. Ajani's Welcome leverages the resulting flood of creatures to effortlessly pad your life total on every iteration. Finally, Zopandrel's own built-in sacrifice ability allows you to pay for its activation costs using the newly spawned tokens, keeping the cycle going infinitely as long as you have enough permanents to feed the engine.