Simic Ascendancy + Master Biomancer + Colossification

Simic Ascendancy

Master Biomancer

Colossification

How it works

1. Cause another creature to enter the battlefield under your control with at least 22 +1/+1 counters on it due to Master Biomancer.
2. Simic Ascendancy's second ability triggers, putting 22 growth counters on Simic Ascendancy.
3. At the beginning of your next upkeep, Simic Ascendancy's third ability triggers, causing you to win the game.

This clever setup hinges on Master Biomancer, whose passive ability supercharges any incoming creature with additional +1/+1 counters equal to its massive power. By slapping Colossification onto Master Biomancer itself, you inflate its power to astronomical heights, ensuring that the next creature you cast enters the battlefield carrying at least twenty-two counters. That sudden influx of stats instantly satisfies Simic Ascendancy's second ability, loading the enchantment with more than enough growth counters to trigger its alternative win condition at the start of your next upkeep.