Aetherflux Reservoir + Cloudstone Curio + Defiler of Instinct

Aetherflux Reservoir

Cloudstone Curio

Defiler of Instinct

How it works

1. Cast the red permanent card in your hand by paying 2 life.
2. Defiler of Instinct and Aetherflux Reservoir triggers.
3. Resolve the Defiler of Instinct trigger, dealing 1 damage to any target.
4. Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast before it this turn.
5. The red permanent enters the battlefield, triggering Cloudstone Curio, returning another nontoken nonartifact red permanent with mana cost from the battlefield to your hand.
6. Repeat.