Wheel of Misfortune + Pariah's Shield + Screaming Nemesis
Wheel of Misfortune
Pariah's Shield
Screaming Nemesis
Near-infinite damage to one opponent
How it works
Cast Wheel of Misfortune by paying 2, choosing an arbitrarily large number and having Wheel of Misfortune deal that much damage to Screaming Nemesis instead of you due to Pariah's Shield if you chose the largest number.
Screaming Nemesis triggers, dealing that much damage to an applicable target.