Wheel of Misfortune + Screaming Nemesis + With Great Power . . .

Wheel of Misfortune

Screaming Nemesis

With Great Power . . .

How it works

1. Cast Wheel of Misfortune by paying 2, choosing an arbitrarily large number and having Wheel of Misfortune deal that much damage to Screaming Nemesis instead of you due to With Great Power... if you chose the largest number.
2. Screaming Nemesis triggers, dealing that much damage to an applicable target.

This clever setup turns Wheel of Misfortune's high-number self-inflicted damage into a lethal weapon by letting you deliberately choose the highest number while enchanted by With Great Power . . ., which redirects all damage that would be dealt to you straight to Screaming Nemesis instead. Because Screaming Nemesis is dealt that massive chunk of damage, its triggered ability immediately fires off and funnels that exact same astronomical amount of damage directly into an opponent.