Wheel of Misfortune + Mogg Maniac + Pariah's Shield
Wheel of Misfortune
Mogg Maniac
Pariah's Shield
Near-infinite damage to one opponent
How it works
Cast Wheel of Misfortune by paying 2, choosing an arbitrarily large number and having Wheel of Misfortune deal that much damage to Mogg Maniac instead of you due to Pariah's Shield if you chose the largest number.
Mogg Maniac triggers, dealing that much damage to an applicable target.