Zedruu the Greathearted + Knowledge Pool + Colfenor's Plans
Zedruu the Greathearted
Knowledge Pool
Colfenor's Plans
Exile all spells target opponent casts from their handTarget opponent can only cast one spell per turnTarget opponent skips their draw stepLock
How it works
Activate Zedruu by paying , giving control of Colfenor's Plans to an opponent.
Whenever the opponent that controls Colfenor's Plans casts a spell from their hand, Knowledge Pool triggers, exiling that spell.
Because Colfenor's Plans prevents the opponent from casting more than one spell each turn, the opponent cannot cast the spell permitted by Knowledge Pool, or any other spell that turn.