Agatha's Soul Cauldron + Myojin of Blooming Dawn + Zopandrel, Hunger Dominus + Prosperous Innkeeper

Agatha's Soul Cauldron

Myojin of Blooming Dawn

Zopandrel, Hunger Dominus

Prosperous Innkeeper

How it works

1. Activate Zopandrel using Myojin of Blooming Dawn's ability by removing an indestructible counter from it, creating a 1/1 Spirit creature token for each permanent you control.
2. When the Spirits enter the battlefield, Prosperous Innkeeper's second ability triggers that many times, causing you to gain that much life.
3. Activate Zopandrel by paying 4 life and sacrificing two Spirits, putting an indestructible counter on it.
4. Repeat.
5. If you control at least two additional permanents as the combo starts, this combo nets infinite lifegain and creature tokens.

This loop transforms Myojin of Blooming Dawn's native token-generation into a repeatable engine by using Agatha's Soul Cauldron to grant its ability directly to Zopandrel, Hunger Dominus. With the Cauldron fueling this substitution, Zopandrel can continuously sacrifice two of the resulting creatures and pay life to put an indestructible counter on itself, which also happens to be the exact cost required to activate the Myojin ability again. Meanwhile, Prosperous Innkeeper watches the board fill up with new spirits and converts every single entry into a steady stream of life.