Isochron Scepter + Silence + Seedborn Muse + Teferi, Mage of Zhalfir

Isochron Scepter

Silence

Seedborn Muse

Teferi, Mage of Zhalfir

How it works

1. On each opponent upkeep activate Isochron Scepter to cast Silence, preventing your opponent from casting spells.
2. Seedborn Muse untaps both Isochron Scepter and the mana required to activate it each turn.
3. Teferi, Mage of Zhalfir prevents your opponent from playing spells at instant speed before you are able to cast Silence or in response to Silence.