Isochron Scepter + Silence + Seedborn Muse + Teferi, Time Raveler

Isochron Scepter

Silence

Seedborn Muse

Teferi, Time Raveler

How it works

1. On each opponent upkeep activate Isochron Scepter to cast Silence, preventing your opponent from casting spells.
2. Seedborn Muse untaps both Isochron Scepter and the mana required to activate it each turn.
3. Teferi, Time Raveler prevents your opponent from playing spells at instant speed before you are able to cast Silence or in response to Silence.