Agatha's Soul Cauldron + Myojin of Blooming Dawn + Zopandrel, Hunger Dominus + Soul Warden

Agatha's Soul Cauldron

Myojin of Blooming Dawn

Zopandrel, Hunger Dominus

Soul Warden

How it works

1. Activate Zopandrel using Myojin of Blooming Dawn's ability by removing an indestructible counter from it, creating a 1/1 Spirit creature token for each permanent you control.
2. When the Spirits enter the battlefield, Soul Warden triggers that many times, causing you to gain that much life.
3. Activate Zopandrel by paying 4 life and sacrificing two Spirits, putting an indestructible counter on it.
4. Repeat.
5. If you control at least two additional permanents as the combo starts, this combo nets infinite lifegain and creature tokens.

By using Agatha's Soul Cauldron to exile Myojin of Blooming Dawn, any creature you control with a +1/+1 counter—including Zopandrel, Hunger Dominus itself—gains the Myojin's ability to remove an indestructible counter to flood the board with 1/1 Spirit tokens. Because Zopandrel can pay its phyrexian hybrid mana cost by sacrificing two of those newly minted Spirits and paying 4 life, you can constantly replenish the indestructible counters that fuel the loop. Meanwhile, Soul Warden watches over the endless tide of arriving tokens to endlessly pad your life total, turning Zopandrel's self-preservation into a self-sustaining engine.