Etrata, the Silencer + Roaming Throne + Adric, Mathematical Genius

Etrata, the Silencer

Roaming Throne

Adric, Mathematical Genius

How it works

1. Deal combat damage to an opponent using Etrata, triggering its ability twice due to Roaming Throne.
2. Holding priority, activate Adric by paying 2 and tapping it, copying either of Etrata's triggers.
3. Resolve all Etrata triggers, exiling three creatures an opponent controls and putting hit counters on them, and then causing that opponent to lose the game.

This assassination loop centers around Etrata, the Silencer sneaking past blockers to deal combat damage, which normally triggers her exile and win-condition counter. By naming "Assassin" for Roaming Throne, Etrata's damage trigger gets a built-in double-tap, flooding the opponent's exile zone with hit counters even faster. Adric, Mathematical Genius then steps in as the mastermind, using his activated ability to copy those very same triggers on demand. Together, this trio quickly stacks up three exiled cards with hit counters, abruptly ending an opponent's game out of nowhere.