Skirk Fire Marshal + Melira, the Living Cure + Triumph of the Hordes

Skirk Fire Marshal

Melira, the Living Cure

Triumph of the Hordes

How it works

1. Cast Triumph of the Hordes by paying 2, giving creatures you control +1/+1 and infect until end of turn.
2. Activate Skirk Fire Marshal by tapping five Goblins you control, putting ten -1/-1 counters on each creature and giving each opponent ten poison counters, and you one poison counter.
3. Each opponent loses the game due to having ten poison counters.