Sway of the Stars + Myojin of Roaring Blades + Alchemist's Refuge
Sway of the Stars
Myojin of Roaring Blades
Alchemist's Refuge
Each opponent loses the gameNear-infinite lifeloss for all playersShuffle all hands, graveyards and permanents on the battlefield into their owner's library
How it works
Activate Alchemist's Refuge's second ability by paying and tapping it, allowing you to cast spells as though they have flash this turn.
Activate Myojin of Roaring Blades by removing an indestructible counter from it.
Holding priority, cast Sway of the Stars by paying 8, causing each player to shuffle their hand, graveyard and all permanents they own into their library, then causing each player to draw seven cards and set their life total to 7.
Resolve the Myojin of Roaring Blades ability, dealing 7 damage to each of up to three opponents.
Each opponent loses the game due to having 0 life.