Activate Champion of the Weird by paying 1 life and putting two -1/-1 counters on Vengeful Vampire.
Vengeful Vampire dies due to having 0 toughness, triggering its undying ability and Dross Harvester
Resolve the Dross Harvester trigger, causing you to gain 2 life.
Resolve the Vengeful Vampire trigger, returning it from your graveyard to the battlefield with a +1/+1 counter on it.
Resolve the Champion of the Weird ability from step 1, causing an opponent to blight 2.
Activate Champion of the Weird by paying 1 life and putting two -1/-1 counters on Vengeful Vampire, causing an opponent to blight 2.
Repeat.
This clever loop harnesses the life-gaining cushion of Dross Harvester to continuously sustain the self-inflicted costs demanded by Champion of the Weird. Each cycle, Champion of the Weird targets Vengeful Vampire with two -1/-1 counters, reducing its toughness to zero and triggering its undying ability to return it with a +1/+1 counter. While the -1/-1 and +1/+1 counters annihilate each other as a state-based action, Dross Harvester steps in upon the vampire's death to recoup the life lost from the champion's activation, allowing you to repeat the process indefinitely for endless blighting and death triggers.