Grollub + Tainted Remedy + Volcano Hellion + Angel's Grace

Grollub

Tainted Remedy

Volcano Hellion

Angel's Grace

How it works

1. Cast Angel's Grace by paying , causing you to be unable to lose the game this turn.
2. Cast Volcano Hellion by paying 2.
3. Volcano Hellion enters the battlefield, dealing an arbitrarily large amount of damage to Grollub and reduing your lifetotal to one due to Angel's Grace.
4. Grollub triggers, causing each opponent to lose life equal to the damage dealt to it due to Tainted Remedy.
5. Each opponent loses the game due to having zero or less life.

This clever setup relies on turning a massive wave of healing into lethal life loss, beginning with Angel's Grace to safely insulate you from your own self-inflicted harm and prevent you from losing the game this turn. When you cast Volcano Hellion, its enters-the-battlefield trigger is aimed squarely at Grollub and yourself for an arbitrarily large amount of damage, which is safely capped at leaving you at 1 life thanks to Angel's Grace. As Grollub takes that monumental blow, its damage-triggered ability normally grants life to each opponent, but the presence of Tainted Remedy inverts that life gain directly into massive life loss, instantly draining them down to zero or less and closing out the game.