Simic Ascendancy + Master Biomancer + Eldrazi Conscription + Colossus Hammer

Simic Ascendancy

Master Biomancer

Eldrazi Conscription

Colossus Hammer

How it works

1. Cause another creature to enter the battlefield under your control with at least 22 +1/+1 counters on it due to Master Biomancer.
2. Simic Ascendancy's second ability triggers, putting 22 growth counters on Simic Ascendancy.
3. At the beginning of your next upkeep, Simic Ascendancy's third ability triggers, causing you to win the game.

This explosive combination relies on scaling a single creature's entry stats straight to a win condition, using Master Biomancer as the heavy-lifting engine that turns any new arrival into a giant. To make the math work, you first enhance Master Biomancer's power using massive aura and equipment buffs from Eldrazi Conscription and Colossus Hammer, ensuring its replacement effect bestows twenty-two or more additional +1/+1 counters onto whatever creature follows it onto the battlefield. Because those counters are placed immediately upon entry, Simic Ascendancy instantly absorbs twenty-two growth counters in one fell swoop, leaving you completely set up to trigger its upkeep win condition on your very next turn.