Windfall + Nekusar, the Mindrazer + Triumph of the Hordes

Windfall

Nekusar, the Mindrazer

Triumph of the Hordes

How it works

1. Cast Triumph of the Hordes by paying 2, giving creatures you control infect until end of turn.
2. Cast Windfall by paying 2, causing each player to discard their hand and then draw a number of cards equal to the greatest number of cards a player discarded this way.
3. Nekusar triggers for each card drawn this way, giving each opponent a poison counter for each card they drew.
4. Each opponent loses the game due to having ten or more poison counters

This lethal sequence begins by dropping Triumph of the Hordes to arm your creatures with infect, transforming any subsequent damage into game-ending poison counters. You then cast Windfall to force a massive hand refill across the table, capitalizing on Nekusar, the Mindrazer's static ability that triggers whenever an opponent draws a card. Because Nekusar deals 1 damage for each of those drawn cards, the resulting flood of damage translates directly into lethal poison counters under the rules of infect, wiping out your opponents in one fell swoop.