Windfall + Nekusar, the Mindrazer + Phyresis

Windfall

Nekusar, the Mindrazer

Phyresis

How it works

1. Cast Windfall by paying 2, causing each player to discard their hand and then draw a number of cards equal to the greatest number of cards a player discarded this way.
2. Nekusar triggers for each card drawn this way, giving each opponent a poison counter for each card they drew.
3. Each opponent loses the game due to having ten or more poison counters