This brilliant extra-turn loop relies on the way legendary permanents and exile effects interact with copying spells. When you cast Karn's Temporal Sundering, The Sixth Doctor triggers to make a nonlegendary copy that grants you an extra turn while the original sits on the stack. Before that original resolves, you use Isochron Scepter—which has previously imprinted Unsubstantiate—to cast a free copy of Unsubstantiate targeting that very same original Karn's Temporal Sundering. This bounces the original back to your hand so you can recast it on your next turn, leaving the exiled card safely away from Karn's Temporal Sundering's own exile clause.