Etrata, the Silencer + Tawnos, Urza's Apprentice + Lithoform Engine

Etrata, the Silencer

Tawnos, Urza's Apprentice

Lithoform Engine

How it works

1. Deal combat damage to an opponent using Etrata, triggering its ability.
2. Holding priority, activate Lithoform Engine's first ability by paying 2 and tapping it, targeting Etrata's trigger.
3. Holding priority, activate Tawnos by paying and tapping it, copying Lithoform Engine's trigger, targeting Etrata's trigger.
4. Resolve both Lithoform Engine triggers, copying Etrata's trigger twice.
5. Resolve all Etrata triggers, exiling three creatures an opponent controls and putting hit counters on them, and then causing that opponent to lose the game.

Etrata, the Silencer naturally slips past defenses and threatens to slowly accumulate hit counters on an opponent's creatures, but we can drastically accelerate this win condition using clever copying effects. When Etrata deals combat damage and triggers her exile ability, Lithoform Engine steps in to duplicate that trigger by paying two mana and tapping. To supercharge the setup, Tawnos, Urza's Apprentice can then use his activated ability to copy Lithoform Engine's own ability, ultimately yielding three total instances of the trigger. By multiplying the effect in a single combat step, you instantly exile three different creatures and immediately trigger the alternate-win condition to make your opponent lose the game on the spot.