Mairsil, the Pretender + Spikeshot Elder + Tree of Perdition

Mairsil, the Pretender

Spikeshot Elder

Tree of Perdition

How it works

1. Activate Mairsil using Tree of Perdition's ability by tapping it, exchanging target opponent's life total with Mairsil's toughness.
2. Activate Mairsil using Spikeshot Elder's ability by paying 1, dealing damage equal to Mairsil's power to the opponent.
3. The opponent loses the game due to having zero or less life.